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Research on possible New Options in future Fertility Treatment

Read about the interesting findings by international research colleagues of Stanford University, Akita University; and the Chinese Academy of Sciences in the NIH 8/4/10 news release (1). Following is a brief excerpt:

Researchers supported by the [NIH] have for the first time activated mouse egg cells at the earliest stage of their development and brought them to maturity. In a related experiment, the researchers replicated the finding by also bringing human eggs to maturity in the laboratory....Current infertility treatment techniques stimulate immature eggs so they develop to the stage at which the eggs can be fertilized, but these techniques work only on eggs at a comparatively late stage of development. These later-stage eggs are few in number and much more difficult to recover than the early-stage eggs used by the researchers in this study. ...The researchers plan to continue their research in animals, examining the safety of the PTEN blocker and other activating agents and testing the feasibility of auto-transplants, in which the stimulated ovarian tissue would be transplanted to a patient’s arm or elsewhere in the body to mature. Such transplanted tissue would be easy to retrieve when the mature eggs are ready for fertilization.

(1) http://www.nih.gov/news/health/aug2010/nichd-04.htm, news from online Proceedings of the National Academy of Sciences; http://www.nichd.nih.gov/news/releases/080410-mature-egg-cells.cfmFirst author Jing Li conducted the research with Stanford University colleagues Yuan Cheng, Cynthia Klein and Aaron J.W. Hsueh; Kazuhiro Kawamura of Akita University; and Shuang Liu, Shu Liu and En-Kui Duan of the Chinese Academy of Sciences. NICHD sponsors research on development, before and after birth; maternal, child, and family health; reproductive biology and population issues; and medical rehabilitation.

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